Various types of polymer with different physical properties (such as biodegradable, non-biodegradable, permeable, etc.) have been used in microparticles preparation. Microparticles have been prepared with a wide range of polymers and polymer blends 1, 2. Water insoluble polymers are usually used as encapsulation matrix for these microparticles. Solvent evaporation method is a popular technique for the encapsulation of drugs within polymeric microparticles. The requirement to ensure the manufacture of a repeatable product necessitates the ability to produce microparticulate particle sizes and distributions within defined limits 1, 2, 3, 4, 5. Microparticle friability, microparticle flowability, tablet weight variance, tabletability, microparticle bulk density, tablet porosity, and tablet dissolution rate are all important parameters to be considered 1, 2, 3, 4, 5. Microencapsulation is a typical unit operation used in the production of solid dosage types including tablets, capsules, and sachets. The FBRM data revealed that the polymer type had a significant impact on microparticle CLD and the transformation process. The FBRM CLDs revealed that a larger particle size mean resulted in a longer CLD and a lower peak of particle number. Hardening time for the transformation of emulsion droplets into solid microparticles occurred within the first 10.5, 19, 25, 30, and 55 min, according to FBRM results. For all three produced batches tested, FBRM, laser diffraction, and sieve analysis yielded similar results. The timing of the FBRM determinations was coordinated with the selection of microparticle samples for particle size analysis by optical microscope and laser diffraction calculation as a reference. The chord lengths and CLD data were taken at specific times using an online FBRM probe mounted below the microparticle.

FBRM was also utilized to measure the length-weighted chord length distribution (CLD) and particle size distribution (PSD) online during particle solidification, which could not be done with laser diffraction or nested sieve analysis. In this paper, we use FBRM measurements to investigate the effects of polymer type and compare the size distributions to those obtained using other sizing methods such as optical microscope and laser diffraction. The online real-time particle size analysis of the microencapsules manufacturing process using the continuous solvent evaporation method was performed using focused beam reflectance measurement (FBRM).

Roland g 600